Experimental Rugged Fitness Landscape in Protein Sequence Space
نویسندگان
چکیده
منابع مشابه
Experimental Rugged Fitness Landscape in Protein Sequence Space
The fitness landscape in sequence space determines the process of biomolecular evolution. To plot the fitness landscape of protein function, we carried out in vitro molecular evolution beginning with a defective fd phage carrying a random polypeptide of 139 amino acids in place of the g3p minor coat protein D2 domain, which is essential for phage infection. After 20 cycles of random substitutio...
متن کاملEvolution in a rugged fitness landscape.
Kauuman's NK-model for genetic evolution and adaption is analysed for K = N ?1. In this case it describes adaptive walks on random tness landscapes, and its dynamics is equivalent to the Metropolis algorithm for Derrida's Random Energy Model at zero-temperature. We derive analytical expressions for the average length and duration of adaptive walks, and for the variance about these averages. The...
متن کاملReflections on Researching the Rugged Fitness Landscape
The success of an informing system depends upon achieving a fit between multiple entities: the sender, the client, the delivery system, and the task to be performed. Conceptually, the effectiveness of such informing can be modeled as a fitness landscape—a function that maps the characteristics of the system into a scalar fitness value. The assumed shape of that landscape plays a major role in d...
متن کاملSmoothing a rugged protein folding landscape by sequence-based redesign
The rugged folding landscapes of functional proteins puts them at risk of misfolding and aggregation. Serine protease inhibitors, or serpins, are paradigms for this delicate balance between function and misfolding. Serpins exist in a metastable state that undergoes a major conformational change in order to inhibit proteases. However, conformational labiality of the native serpin fold renders th...
متن کاملSelf-Organization in Models of Populations with Two-Parent Reproduction on a Rugged Fitness Landscape
The two-parent reproduction model of Derrida and Peliti is simulated on a rugged tness landscape. Fixed tness values for each possible genotype are assigned randomly, with all t individuals having the same probability of reproduction. The previously observed transition to a self-organized state of the population with less recombinational load, implies an abrupt change of genetic overlap distrib...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS ONE
سال: 2006
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0000096